Berberine 250 x 120 Capsules

Berberine capsules with concentrated berberine extract, appear to have multiple roles within the body. It has an anti-inflammatory action on the pathways of oxidative stress and inflammation that contribute to the pathogenesis of various diseases, including Type 2 Diabetes Mellitus (T2DM). Specifically, berberine has been shown to influence various kinase and signaling pathways, affecting adipocytes and immunocytes to produce interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), thereby reducing levels of NF-kB and AMP-activated protein kinases (AMPK).

Berberine extract acts as a powerful antioxidant, inhibiting oxidative stress, which is also associated with the development of insulin resistance, it may also promote healthy blood sugar levels by decreasing glucose absorption in the gut and glucose synthesis, while increasing pancreatic insulin secretion, insulin sensitivity, and glucose breakdown.

Allergy Research Berberine capsules may support healthy cholesterol metabolism by inhibiting cholesterol absorption in the gut, increasing cholesterol excretion into the bile, and decreasing cholesterol synthesis.

Berberine extract also play a role in maintaining a balanced gut microbiota. It increases levels of Akkermansia muciniphila, which is associated with a lower BMI and better blood sugar management. A. muciniphila has also been shown to improve gut tight junction integrity and attenuate LPS-induced inflammation.

Additionally, berberine extract decreases intestinal permeability and increases gut production of butyrate, a beneficial SCFA.

Berberine supports bile acid metabolism, reduce lipid peroxidation, and exhibit cholagogue and choleretic actions, further promoting digestive and metabolic health.