Biomega-SPM x 60 Softgels

Biomega-SPM™ supports the body’s natural inflammatory response through a sophisticated molecular pathway. Derived from omega-3 fatty acids, these precursor molecules play an integral role in the body’s natural inflammatory process, from initial activation to active resolution phases, supporting overall healing.

Understanding SPM Precursors

Specialised Pro-Resolving Mediators (SPMs) are critical compounds innately produced by the body to support the natural inflammatory process.1,2 These end-products are involved in the normal physiological transition from initial immune activation to the restoration of tissue balance. The body creates SPMs from the omega-3 fatty acids EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), which are found in certain foods and dietary supplements.

Supplementing with omega-3 fatty acids and their metabolites may help support the body’s normal physiological processes. Studies suggest that precursors to SPM’s may influence cellular responses and support the body’s natural ability to maintain comfortable joint function and mobility.

The Science of SPM Precursors

SPM precursors are naturally present in human blood, milk, and brain tissue, initiating a complex metabolic cascade.5,6 This pathway begins with omega-3 fatty acids (EPA/DHA/DPA), which are transformed into specific metabolites, including:

18-HEPE

17-HDHA

14-HDHA

7-HDPA

13-HDPA

17-HDPA

5-HETE

These intermediary metabolites serve as the foundational building blocks that the body can convert into specialised pro-resolving mediators (SPMs) which include lipoxins, resolvins, maresins, and protectins. Each precursor plays a specific role in supporting the body’s natural physiological processes of inflammation resolution.

Advanced Processing Technology 

Biomega-SPM™ utilises a proprietary supercritical extraction process with an 8-stream fractionation system that yields an impressive 1000 μg/gram of precursors to pro-resolving mediators. Each softgel contains 250 μg of these valuable precursors.

Biomega- SPM™ delivers a high concentration in the smallest possible softgel format for optimal patient compliance.
 

Biomega-SPM™ may support –

• Normal cellular responses to physiological challenges
• Healthy immune cell function
• Natural maintenance of joint comfort and mobility
• Normal cardiovascular function
• Natural maintenance of tissue homeostasis

Biomega-SPM™ may also help address –

• Age-related change in inflammatory responses
• Physical stressors
• Nutritional imbalances
• Long-term inflammatory balance.

References: 

1. Basil MC, Levy BD. Specialized pro-resolving mediators: endogenous regulators of infection and inflammation. Nat Rev Immunol. 2016 Jan;16(1):51-67.

2. Serhan CN. Resolution phase of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathways. Annu Rev Immunol. 2007;25:101-37. 

3. Reinertsen AF, Vik A, Hansen TV. Biology and Total Synthesis of n-3 Docosapentaenoic Acid-Derived Specialized Pro-Resolving Mediators. Molecules. 2024 Jun 14;29(12):2833. 

4. Markworth JF, Vella L, Lingard BS, et al. Human inflammatory and resolving lipid mediator responses to resistance exercise and ibuprofen treatment. Am J Physiol Regul Integr Comp Physiol. 2013 Dec;305(11):R1281-96. 

5. Serhan CN, Petasis NA. Resolvins and protectins in inflammation resolution. Chem Rev. 2011 Oct 12;111(10):5922-43. 

6. Weiss GA, Troxler H, Klinke G, et al. High levels of anti-inflammatory and pro-resolving lipid mediators lipoxins and resolvins and declining docosahexaenoic acid levels in human milk during the first month of lactation. Lipids Health Dis. 2013 Jun 15;12:89. 

7. Souza PR, Marques RM, Gomez EA, et al. Enriched Marine Oil Supplements Increase Peripheral Blood Specialized Pro-Resolving Mediators Concentrations and Reprogram Host Immune Responses: A Randomized Double-Blind Placebo-Controlled Study. Circ Res. 2020 Jan 3;126(1):75-90. 

8. Sobrino A, Walker ME, Colas RA, et al. Protective activities of distinct omega-3 enriched oils are linked to their ability to upregulate specialized pro-resolving mediators. PLoS One. 2020 Dec 16;15(12):e0242543.
9. Schaller MS, Chen M, Colas RA, et al. Treatment With a Marine Oil Supplement Alters Lipid Mediators and Leukocyte Phenotype in Healthy Patients and Those With Peripheral Artery Disease. J Am Heart Assoc. 2020 Aug 4;9(15):e016113. 

10. Cannataro R, Abrego-Guandique DM, Straface N, et al. Omega-3 and Sports: Focus on Inflammation. Life (Basel). 2024 Oct 16;14(10):1315. 

11. Möller I, Rodas G, Villalón JM, et al. Randomized, double-blind, placebo-controlled study to evaluate the effect of treatment with an SPMs-enriched oil on chronic pain and inflammation, functionality, and quality of life in patients with symptomatic knee osteoarthritis: GAUDI study. J Transl Med. 2023 Jun 29;21(1):423. 

12. Lima-Garcia JF, Dutra RC, da Silva K, et al. The precursor of resolvin D series and aspirin-triggered resolvin D1 display anti-hyperalgesic properties in adjuvant-induced arthritis in rats. Br J Pharmacol. 2011 Sep;164(2):278-93. 

13. Callan N, Hanes D, Bradley R. Early evidence of efficacy for orally administered SPM-enriched marine lipid fraction on quality of life and pain in a sample of adults with chronic pain. J Transl Med. 2020 Oct 21;18(1):401. 

14. Barden A, Shinde S, Beilin LJ, et al. Adiposity associates with lower plasma resolvin E1 (Rve1): a population study. Int J Obes (Lond). 2024 May;48(5):725-732. 

15. Hotamisligil GS. Foundations of Immunometabolism and Implications for Metabolic Health and Disease. Immunity. 2017 Sep 19;47(3):406-420.