Butyricum (Previously GI Repair) x 30 Caps

A revolutionary approach to GI discomfort! A healthy, diverse gut microbiome is the key to symptom relief. Pendulum GI Repair takes a holistic approach by creating a butyrate-producing formulation that targets specific pathways linked to GI discomfort. The strain called Clostridium butyricum, the digestive health & butyrate-producing bacterium naturally found in the human GI tract, is named for its ability to produce high amounts of short-chain fatty acid butyrate. It has been associated with digestion support and immune health.

Intestinal immune hoxmeostasis is regulated by gut microbiota, including beneficial and pathogenic microorganisms. Imbalance in gut bacterial constituents provokes host proinflammatory responses causing diseases.

Clostridium butyricum as a probiotic induces interleukin-10-producing macrophages in inflamed mucosa via the Toll-like receptor 2/myeloid differentiation primary response gene 88 pathway as well as the short-chain fatty acid butyrate. As the major source of energy for colonic mucosal cells and as an important regulator of gene expression, inflammation, differentiation, and apoptosis in host cells, microbiota-derived butyrate can enhance the intestinal mucosal immune barrier, modulate systemic immune response, and prevent infections.

Maintaining a certain level of butyrate production in the gut can help balance intestinal microbiota, regulate host immune response, and promote the development and maintenance of the intestinal mucosal barrier. Conditions that are triggered or amplified by local and systemic inflammation induced by alterations in the GI microbiome may benefit from the application of a well-studied probiotic for the induction of counter-regulatory cytokines and fatty acids, such as Clostridium butyricum WB-STR-0006.